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>> BRENDA is maintained and developed at the Institute of Biochemistry and Bioinformatics at the Technical University of Braunschweig, Germany.
>> Data on enzyme function are extracted directly from the primary literature by scientists holding a degree in Biology or Chemistry.
>> Formal and consistency checks are done by computer programs, each data set on a classified enzyme is checked manually by at least one biologist and one chemist.
Today, as the large international genome sequence projects are gaining a great amount of public attention and huge sequence data bases are created, it becomes more and more obvious that we are very limited in our ability to access functional data for the gene products - the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often subject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible applications of this knowledge in the fields of medicine, agriculture, etc.. Recent progress on enzyme immobilisation, enzyme production, enzyme inhibition, coenzyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas.
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